Bio-IT World

July 30, 2020 | July featured thrilling new, merchandise, and partnerships from across the bio-IT neighborhood from innovating firms, organizations, and universities, together with Celsius Therapeutics, Twist Bioscience, and extra.

Celsius Therapeutics introduced the signing of three collaboration agreements with the University of Oxford, Cleveland Clinic, and the LMU University Hospital Munich. In every settlement, Celsius will companion with main educational scientists to entry affected person tissue samples and apply its proprietary single-cell genomics platform and machine studying capabilities to find new insights into inflammatory bowel illness (IBD). Under these collaborations, Celsius will consider a lot of longitudinal (each pre- and post-treatment) samples, together with biopsies from sufferers who reply to or fail anti-TNFa remedy (University of Oxford); Crohn’s illness sufferers who develop illness recurrence following intestinal resection (Cleveland Clinic); and kids with very early onset IBD (LMU University Hospital Munich). Celsius will combine single-cell RNA sequencing knowledge from these samples with medical knowledge offered by its companions to determine novel drug targets and affected person stratification approaches for particular affected person subsets. Under the phrases of every settlement, Celsius retains the power to include each the de-identified medical info and longitudinal single-cell genomics knowledge generated from these research into its giant and repeatedly rising database. Celsius plans to mix the information generated by these agreements with different work utilizing its single-cell genomics and machine studying algorithms to elucidate this sophisticated illness biology. Further, Celsius will mix these insights with orthogonal knowledge units derived from useful genomics and different approaches to confirm organic mechanisms and validate potential drug targets. Press release

Twist Bioscience introduced a partnership with Takeda for entry to proprietary phage show libraries for the invention, validation and optimization of antibodies in Takeda’s pipeline of biologics for oncology, uncommon ailments, neuroscience, and gastroenterology. Under the phrases of the settlement, Twist Biopharma, a division of Twist Bioscience, will license to Takeda its “Library of Libraries,” a panel of artificial antibody phage show libraries derived solely from sequences that exist within the human physique. Together, the businesses will work to find, validate and optimize new antibody candidates. In return, Takeda pays Twist annual know-how licensing charges, in addition to milestones and royalties for all compounds found from the Twist phage show libraries. “We look forward to applying our unique ability to generate robust, diverse and cutting-edge libraries together with Takeda’s deep insight into therapeutic drug discovery and development to truly forge new frontiers in bringing personalized therapies to patients worldwide,” Emily M. Leproust, CEO and co-founder of Twist Bioscience, mentioned in an official assertion. Press release

LabVantage Solutions introduced that the newly-released 8.5 version of its LabVantage platform affords a completely built-in Scientific Data Management System (SDMS). LabVantage SDMS ensures safety and management towards knowledge loss or modification. The non-obligatory SDMS seamlessly interfaces with all parts of the LabVantage platform, together with LIMS (laboratory info administration system), ELN (digital laboratory pocket book), and LES (laboratory execution system). LabVantage 8.5 additionally features a new and complete Configuration Management and Transfer (CMT) function for better LIMS administration productiveness and higher management, together with quite a lot of enhancements that make the LabVantage ELN simpler to make use of. “During these challenging times, we are especially proud to release LabVantage 8.5, which represents a major advance reflecting our commitment to making the advantages of digital transformation fully accessible to our customers,” mentioned John Heiser, CEO of LabVantage, in a press launch. “LabVantage 8.5’s fully integrated SDMS is specifically designed for the LabVantage platform and provides major benefits to laboratory managers, with the aim of making their operations more efficient, productive, and secure. Our user-friendly, all-in-one SDMS offers seamless, continuous data integrity. Importantly, it allows managers to secure all of their data, not just the final results.” The built-in SDMS routinely collects and protects all instrument and different related laboratory knowledge as it’s generated, which offers a wealthy informatics and analytical useful resource that allows higher lab administration, improved high quality, and enhanced safety. Full integration signifies that all related lab-generated knowledge is collected routinely and quickly made obtainable to laboratory workers. Importantly, integration ensures knowledge integrity and safety by eliminating the necessity to switch knowledge between system parts or to go away it with the instrument system, sometimes a weak hyperlink within the course of. Press release

The Josep Carreras Leukaemia Research Institute has created the OneChain Immunotherapeutics (OCI) spin-off, the goal of which is to develop new immuno-oncological therapeutic instruments with varied preclinical candidates, based mostly on CAR-T know-how for various tumors, comparable to cortical T-cell acute lymphoblastic leukemia (coT-ALL), a uncommon subtype of leukemia that primarily impacts youngsters, and which has a poor prognosis. The spin-off is being funded initially by way of a spherical of seed capital offered by Invivo Ventures, the Ministry of Industry, by way of CDTI-Innvierte, and the Josep Carreras Foundation, and it clearly makes the case for bringing the analysis carried out by Dr. Pablo Menéndez‘s group nearer to sufferers. Dr. Mendez is an ICREA analysis professor and the scientific director on the Josep Carreras Leukaemia Research Institute’s Hospital Clínic-UB Campus. “OCI is the vehicle that will enable us to take all the work we have been doing over all these years and apply it to clinical use,” Dr. Menéndez said in an official statement. “At the academic level it is very complicated to develop these strategies and manage all the regulatory mechanisms associated with the development of a product. OCI will enable us to carry out all the necessary steps so that all our knowledge can be available to patients.” Press release

VantAI and TARA Biosystems introduced the launch of a biology-driven, AI-enabled collaboration for accelerated cardiac drug improvement. The partnership will leverage TARA’s state-of-the-art in vitro human biology fashions and VantAI’s main computational drug discovery capabilities to determine and develop new therapies to struggle cardiac illness. Combining the ability of VantAI’s machine learning-enabled gene-disease mapping methods with the wealthy, high-fidelity phenotypic knowledge generated from TARA’s in vitro human cardiac illness fashions, TARA and VantAI will determine novel drug targets linked to cardiac illness. Then, the staff will use VantAI’s in silico platform to provide novel molecules that successfully modulate these targets, lots of which have been beforehand thought-about “undruggable.” VantAI’s platform will prioritize modality methods and use generative approaches to design exact chemistry that’s efficient whereas additionally displaying favorable pharmaceutical properties. The useful response of those novel molecules will then be evaluated in TARA’s induced pluripotent stem cell-derived human cardiac tissue fashions, which embody a repertoire of wholesome, gene-edited, patient-derived, and drug-induced phenotypes of human illness. The TARA fashions symbolize a extremely versatile platform for capturing strong physiologic endpoints of human cardiac operate, together with contractility, electrophysiology, calcium signaling, construction, in addition to genomic, proteomic, and metabolic profiles. These complete experimental outcomes might be fed again to VantAI’s in silico platform to each energy additional refinement of lead candidates and develop the VantAI-TARA joint knowledge graph view of cardiac illness programs. Press release

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