4D Molecular Therapeutics Announces Collaboration on

EMERYVILLE, Calif., May 04, 2021 (GLOBE NEWSWIRE) — 4D Molecular Therapeutics (Nasdaq: FDMT), a clinical-stage gene remedy firm harnessing the facility of directed evolution for focused gene therapies, introduced a brand new collaboration with investigators on the University of California, Berkeley centered on increasing the vector invention energy of 4DMT’s Therapeutic Vector Evolution platform by making use of machine studying expertise to the AAV vector capsid datasets generated from 4DMT’s platform. This analysis can be carried out with Jennifer Listgarten, Ph.D., a worldwide chief in machine studying and computational biology, and David Schaffer, Ph.D., a worldwide chief in AAV directed evolution and gene remedy. Dr. Listgarten is a Professor in U.C. Berkeley’s Center for Computational Biology, the Berkeley Artificial Intelligence Research Lab and the Chan Zuckerberg Biohub. Prior to her present positions, she held management roles in machine studying inside Microsoft Research for roughly 10 years. Dr. Schaffer is Professor of Chemical and Biomolecular Engineering, Molecular and Cell Biology and the Helen Wills Neuroscience Institute at U.C. Berkeley. He can be Co-founder, Director and Chief Scientific Advisor at 4DMT.

“This cross-functional collaboration with world leaders in machine learning and AAV gene therapy technologies gives us the potential to dramatically expand the depth and breadth of targeted and evolved vectors invented through our Therapeutic Vector Evolution platform, significantly expanding our leading vector patent and product portfolios. 4DMT’s industry-leading AAV capsid libraries encompass over one billion synthetic capsid sequences. To our knowledge, we have the largest capsid biodistribution datasets in the world as a result of the over 15 vector selection programs we have conducted in non-human primates,” mentioned David Kirn, M.D., Co-founder and Chief Executive Officer of 4DMT. “This partnership with Drs. Listgarten and Schaffer empowers 4DMT to dramatically expand our bioinformatics capabilities, enabling us to identify even more promising vectors both within, and even beyond, our existing libraries. This partnership reaffirms our commitment to relentless innovation in order to bring cures to patients.”

Therapeutic Vector Evolution combines the facility of directed evolution with roughly one billion artificial capsid sequences to invent advanced vectors to be used in focused gene remedy merchandise. Using its proprietary Therapeutic Vector Evolution platform, up to now 4DMT has generated an industry-leading 40 distinct capsid libraries, carried out greater than 15 vector picks in non-human primates, and has filed patent purposes on over 300 novel AAV vectors. Three of those proprietary vectors had been utilized in medical and/or IND product candidates in ophthalmology (4D-150, 4D-125, 4D-110), cardiology (4D-310) and lung (4D-710). Through these 15 vector picks, 4DMT has generated quite a few {industry} main and expansive datasets referring to capsid biodistribution and supply to focused tissues by means of routine routes of administration, environment friendly transduction of goal cells, and/or resistance to neutralizing antibodies. The utility of machine studying to 4DMT’s Therapeutic Vector Evolution and its datasets represents a chance to leverage an enabling expertise to invent new vectors to be used in focused gene remedy merchandise.

About 4DMT

4DMT is a clinical-stage firm harnessing the facility of directed evolution for focused gene therapies. 4DMT seeks to unlock the complete potential of gene remedy utilizing its platform, Therapeutic Vector Evolution, which mixes the facility of directed evolution with roughly one billion artificial capsid sequences to invent advanced vectors to be used in focused gene remedy merchandise. The firm is initially centered in three therapeutic areas: ophthalmology, cardiology, and pulmonology. The 4DMT focused and advanced vectors are invented with the aim of being delivered by means of clinically routine, well-tolerated and minimally invasive routes of administration, transducing diseased cells in goal tissues effectively, having decreased immunogenicity and, the place related, having resistance to pre-existing antibodies. 4DMT is presently conducting three medical trials: 4D-125 is in a Phase half of medical trial for XLRP sufferers, 4D-110 is in a Phase 1 medical trial for choroideremia sufferers and 4D-310 is in a Phase half of medical trial for Fabry illness sufferers.

4D Molecular Therapeutics™, 4DMT™, Therapeutic Vector Evolution™, and the 4DMT emblem are logos of 4DMT.

Cautionary Note Regarding Forward-Looking Statements

This press launch accommodates forward-looking statements throughout the that means of the Private Securities Litigation Reform Act of 1995, as amended, together with, with out limitation, implied and categorical statements concerning plans and timelines for the medical growth of 4D-310, 4D-125, 4D-110, 4D-150 and 4D-710, together with the therapeutic potential and medical advantages thereof; 4DMT’s potential to dramatically broaden the depth and breadth of the proprietary optimized vectors invented by means of its Therapeutic Vector Evolution platform and its capacity to broaden its vector patent portfolio; whether or not 4DMT’s machine studying collaboration with U.C. Berkeley will broaden its bioinformatics capabilities and whether or not 4DMT will be capable of determine extra promising artificial capsid sequences inside its present libraries; whether or not 4DMT’s machine studying collaboration with U.C. Berkeley might drive extra worth and consequence within the discovery of novel new capsids; and 4DMT’s technique, enterprise plans and focus. The phrases “may,” “might,” “will,” “could,” “would,” “should,” “expect,” “plan,” “anticipate,” “intend,” “believe,” “expect,” “estimate,” “seek,” “predict,” “future,” “project,” “potential,” “continue,” “target” and related phrases or expressions are meant to determine forward-looking statements, though not all forward-looking statements include these figuring out phrases. Any forward-looking statements on this press launch are based mostly on administration’s present expectations and beliefs and are topic to plenty of dangers, uncertainties and essential elements which will trigger precise occasions or outcomes to vary materially from these expressed or implied by any forward-looking statements contained on this press launch, together with, with out limitation, dangers related to: the affect of COVID-19 on nations or areas through which 4DMT has operations or does enterprise, in addition to on the timing and anticipated outcomes of its medical trials, technique and future operations; the delay of any present or deliberate medical trials for the event of 4DMT’s drug candidates, the chance that the outcomes of its medical trials might not be predictive of future ends in reference to future medical trials; 4DMT’s capacity to efficiently show the protection and efficacy of its drug candidates; the timing and consequence of our deliberate interactions with regulatory authorities; and acquiring, sustaining and defending our mental property. These and different dangers and uncertainties are described in larger element within the part entitled “Risk Factors” in 4DMT’s most up-to-date Annual Report on Form 10-Ok that was filed on March 25, 2021, in addition to any subsequent filings with the Securities and Exchange Commission. In addition, any forward-looking statements symbolize 4DMT’s’ views solely as of at this time and shouldn’t be relied upon as representing its views as of any subsequent date. 4DMT explicitly disclaims any obligation to replace any forward-looking statements. No representations or warranties (expressed or implied) are made concerning the accuracy of any such forward-looking statements.

4D-310, 4D-125 and 4D-110 are 4DMT’s product candidates in medical trials and haven’t but been permitted for advertising and marketing by the US FDA or every other regulatory authority. No illustration is made as to the protection or effectiveness of 4D-310, 4D-125, or 4D-110 for the therapeutic use for which they’re being studied.

Contacts:

Media:

Theresa Janke
tjanke@4dmt.com

Investors:

Mike Zanoni
Endurance Advisors
mzanoni@4dmt.com

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