Patent citations may sign which biomedical papers result in a real-world influence

Of the a whole lot of hundreds of scientific papers revealed yearly, it’s not all the time clear which of them will make a real-world influence, whether or not within the realm of bettering remedies or supporting new analysis instruments, like high-powered microscopes.

Now, scientists at Stanford Medicine have developed a system to assist measure the tangible influence of biomedical papers.

The analysis crew created a metric that depends on patent citations. Scientists who file a patent, which marks the transition of an thought or discovering to an precise product or course of, should checklist scientific papers from which their thought drew. The references to papers are referred to as patent citations.

The researchers opted to trace patent citations as a approach to measure the influence of a scientific manuscript, given patents typically function a basis for brand new firms or merchandise. They reasoned that papers cited in a patent are those most definitely to tell real-world change and innovation.

“We all know that many breakthroughs in the clinic and in technology come from basic findings or innovations in the lab, but the process by which one actually translates that science to the real world is opaque,” mentioned Ishan Kumar, a graduate pupil at Stanford. The crew hopes its new metric won’t solely assist join the dots however will present a brand new lens via which translational productiveness at universities and establishments might be characterised.

Zou and his colleagues additionally discovered that racially and ethnically numerous analysis groups had been considerably extra more likely to publish papers that had been cited in patents. They primarily based their range assessments on identify evaluation. Additionally, the info confirmed that papers with a feminine lead or senior creator had been much less more likely to be listed in a patent quotation.

A paper describing the examine was revealed right now in Nature Biotechnology. Kumar and James Zou, PhD, professor of biomedical knowledge science, are co-senior authors. Stanford medical pupil Anoop Manjunath is the lead creator.

The proof is within the patent

It’s been troublesome to decipher which scientific discoveries will transfer from the lab to the clinic or into industrial use, in addition to the demographic traits of these whose work is more likely to make the transition, Zou mentioned. Typically, the influence of scientific papers is measured via one thing referred to as a research-citation issue, which measures the variety of instances different scientists consult with a sure paper in their very own work. There are inherent limitations with that strategy: A researcher could also be extra inclined to quote papers from colleagues or pals, for example, and citations don’t seize the total extent of their paper’s affect — however it nonetheless gives some indication of a paper’s influence.

Zou and his crew didn’t got down to change this barometer, however quite to complement it with one thing conventional quotation components don’t measure.

“It’s incredibly difficult — but important — to measure translation and innovation,” Zou mentioned. “Once we can do that, it opens doors to measure other things, too, like how federal funding affects scientific discovery and innovation at universities.”

It’s extremely troublesome — however essential — to measure translation and innovation.

In devising their new methodology of analysis, the crew aggregated 2.four million scientific publications from PubMed and 125 million patents filed within the Google Patent Public Datasets from 1970 to 2015. Tey then created an algorithm to hyperlink the analysis with the patents. In the examine, papers cited in a patent had been seen as extra straight linked to the interpretation of concepts into observe.

After parsing the info, the crew noticed that papers from biomedical analysis powerhouses such because the University of California system, Johns Hopkins University and Stanford University ranked excessive in patent citations. But additionally they noticed that some smaller establishments that produce fewer papers general, such because the Broad Institute, additionally ranked within the high tier, suggesting that smaller, specialised organizations can have simply as a lot, if no more, of a translational influence per publication in terms of biomedical improvements.

Diversity and gender results

While analyzing the info for added insights, two traits stood out to Zou and the crew: Papers with a feminine first or senior creator had been much less more likely to be cited in a patent. What was significantly shocking, mentioned Manjunath, was that the gender hole endured throughout the 45-year interval they examined. “We know that in many other academic fields, there certainly has been a demographic change, especially over the last few years, but that hasn’t really been reflected in the pattern of citations,” he mentioned. That could also be, partly, as a result of longer lag time in patent citations, Manjunath mentioned, including that maybe the gender hole in patent citations will shut within the coming years.

The second pattern that caught the crew’s consideration was that publications with extra racially and ethnically numerous authors had been considerably extra more likely to be cited in a patent compared with papers with a much less numerous group of authors. This pattern persists after accounting for the scientific area.

“We all have lots of experiences working with other scientists from different countries who have different backgrounds and ideas. And I think we’re intuitively aware that having more diverse teams improves the quality of research and the innovativeness of teams overall,” Zou mentioned. “But what’s really nice about the analysis Anoop and Ishan did was they actually measured innovation outcomes as it correlates with diversity. That’s interesting, even if it’s just correlative at this point.”

In different phrases, the evaluation can’t show that the variety of the groups is what brought on the upper variety of patent citations, however the findings recommend a hyperlink between range and innovation, Zou mentioned.

Manjunath and Kumar are in search of out among the causes the gender hole in patent citations seems to be so persistent. The crew is conducting interviews with scientists — from masters of patent submitting to these and not using a patent to their identify — to raised perceive the method and why some papers is perhaps ignored.

“My hope is that the feedback we get will help inform how to make changes, perhaps at a policy level, so that there are equitable opportunities to be rewarded for one’s work,” Kumar mentioned.

Research affiliate Arya Gowda is a Stanford co-author on the paper.

Researchers from Carnegie Mellon University, University of Illinois, Columbia University and Chan-Zuckerberg Biohub contributed to the examine.

The examine was funded by the National Science Foundation, the Silicon Valley Foundation and the Chan Zuckerberg Initiative.


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